Highest Occupied Molecular Orbital. The interaction of a molecular HOMO with the LUMO (lowest unoccupied molecular orbital) of another molecule is the basis of intermolecular bond formation.
2. a term that has been reclaimed by some gay/queer communities that is used affectionately between community members to mean someone wonderfully, sublimely gay.
1. did you see those two punks kissing? what homos.
2. guy: "i love lillies, and soccer players."
fellow queer says: "you're my favorite homo"