Pick-up-till-put-down Syndrome

A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.

Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.

by NinjaSlayer_936 January 02, 2021

dj down syndrome

Samsquatch, jef

My name is DJ down syndrome but you can call me Jef

by DJ DOWNSYNDROME November 20, 2017

autistic cancer down syndrome brain damaged mentally challenged sponge

Defines people who dabs

He is autistic cancer down syndrome brain damaged mentally challenged sponge

by autistic cancer downs boy March 09, 2017

Hackney Downs Syndrome

Condition where someone moves to Hackney, grows stupid facial hair, starts wearing braces and woolly hats and riding a fixie retro bicycle, turns Vegan suddenly and decorates their home with overpriced unwanted furniture and recycled pallets. Even buys a turntable.

Since Colin moved to Dalston, he’s turned into a right wanker. That guys got a serious case of Hackney Downs Syndrome.

by Blah wars September 30, 2018

Down syndromic

Just another way to call someone with Down syndrome

Look at that retard he’s so down syndromic

by Sellout President September 05, 2023

Deployment Driven Down Syndrome

A neurological disorder generally presenting itself in males aged 18-40 as a result of deploying to environments that are so hot the brain cooks inside of a helmet that is bombarded by high frequency radio waves and X-ray radiation while simultaneously trying to figure out exactly what the mission is. The people who are handicapped by this syndrome return noticably impaired in both mental and physical capabilities.

My uncle has Deployment Driven Down Syndrome (DDDS). He spent 9 months looking at the same patch of desert for 8 hours a day during OSS while running a backscatter.

by The Cap N' August 21, 2023

Down Syndrome Ass

A large and disproportionate butt

Yo Trayvon, have you seen Lynteria's ass lately. That girl is walking around with a down syndrome ass without even knowing it.

by White Boi Brain January 17, 2024