Pick-up-till-put-down Syndrome

A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.

Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.

by NinjaSlayer_936 January 1, 2021

Down Syndrome

Also known as Trisomy 21. With 23 pairs of chromosomes, a person with Down Syndrome (i.e., a retard) has an extra 21st chromosome, causing several physical and mental defects. Usually easily recognized due to the retarded shape of their face and the clueless, happy expression on their face. These poor brain-dead sacks of sweaty garbage might be able to hold down a job as a greeter at Walmart, but this is about as high up the corporate ladder that these circus freaks typically go.

"Oh my god, did you see that dipshit window-licker trying to parallel park a shopping cart? What a down syndrome, fat fucking gay retard, fucking just dumbass stupid fucking loser. Let's kill him. I'll drown his ass, what a fucking puke piece of shit."

by Jack-the-stripper-ripper May 2, 2025

Down syndrome

Someone with an extra chromosome

He liking his balls i think he has Down syndrome

by Illegal border hopper April 21, 2022

Hackney Downs Syndrome

Condition where someone moves to Hackney, grows stupid facial hair, starts wearing braces and woolly hats and riding a fixie retro bicycle, turns Vegan suddenly and decorates their home with overpriced unwanted furniture and recycled pallets. Even buys a turntable.

Since Colin moved to Dalston, he’s turned into a right wanker. That guys got a serious case of Hackney Downs Syndrome.

by Blah wars September 30, 2018

down syndrome

cody zinkus down syndrome

cody zinkus looks like a sped down syndrome

by bubblebath280 December 20, 2023

FaZe Down syndrome

FaZe Down syndrome is when a fan of the Call of Duty league franchise "Atlanta FaZe" becomes so obsessed with the team that all logic flies out the window

Symptoms include:
Agreeing with everything a faze player says
Making awful excuses about why faze lost a game (eg. "It was Rigged!")
Arguing with anyone on twitter who says faze isn't the best

That guy over there thinks simp is greater than Scump he obviously has FaZe Down Syndrome

by Realistic faze fab January 21, 2023

Down Syndrome

when you have all the chromosones

Yea Nathan have down syndrome

by boudaciousslayqueen420 June 9, 2022