To talk someone down is to speak to them in a soothing voice in an attempt to calm them down, especially when they're vomit-drunk or having a bad trip. This usually takes place behind or next to the person having a bad trip, in front of a bathroom mirror in a stranger's house while your best friend is curled up in a ball in the bathtub and someone already has the toilet.
I wanted to roll over and die after the third hit, but thanks to Derek talking me down I was okay.
An expression used commonly to refer to a seemingly impending fight or confrontation that will usually result in someone or multiple persons getting the shit beat out of them. Often heard when one person insults another's mother or girlfriend and the man insulted enough is ready to flip.