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To talk someone down is to speak to them in a soothing voice in an attempt to calm them down, especially when they're vomit-drunk or having a bad trip. This usually takes place behind or next to the person having a bad trip, in front of a bathroom mirror in a stranger's house while your best friend is curled up in a ball in the bathtub and someone already has the toilet.
I wanted to roll over and die after the third hit, but thanks to Derek talking me down I was okay.

She should be alright after a good talk down.
by anglosaxophone October 25, 2015
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To speak to someone or about something in a condescending manner or tone.
Uncle Shane, why do you talk down about gay people all the time?
by dag mcfag October 04, 2019
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