To have made a massive, catastrophic blunder. An extension of the more common "screwed the pooch," which adds a more severe consequence to the metaphorical action.
Since invading Iraq, President Bush and his advisors have really screwed the pooch and knocked it up.
by ElOjo January 9, 2008

makin a letter or sign wit your fingers, lettin people know wat crew you wit
cripsz would put up 2 C'sz
Bloodsz would put up a b
People from Atlanta would make a A
cripsz would put up 2 C'sz
Bloodsz would put up a b
People from Atlanta would make a A
by LocMamii April 25, 2006

the way that a redneck, usually one that hails from the Southern United States, refers to their pick-up truck. The added "'em" is the addition of Southern dialogue to the general name of a common type of truck, and usually makes the person driving appear to be of low intelligence
Cletus: Its a darn tootin fine day here in Mobile, Alabama.
BillyJoe: sure is Cletus, its mighty-fine. Wanna go for a ride in my fancy Ford F-150 pick 'em up truck?
Cletus: Yeeeeeeeehaw lets go!!!
BillyJoe: sure is Cletus, its mighty-fine. Wanna go for a ride in my fancy Ford F-150 pick 'em up truck?
Cletus: Yeeeeeeeehaw lets go!!!
by BossMan94 July 26, 2011

by Berry January 17, 2004

a. Pleases me.
b. Turns me on.
b. Turns me on.
a. "Yeah, I enjoyed 'The Matrix,' but a really good film like 'Run Lola Run' is more the kinda thing that really blows my skirt up."
b. "There is not one single damned so-called 'Hollywood Hunk' these days who blows my skirt up at all. Where in hell are the good-looking men?"
b. "There is not one single damned so-called 'Hollywood Hunk' these days who blows my skirt up at all. Where in hell are the good-looking men?"
by Sport September 9, 2003

by Momma's Boy May 13, 2005

Me:stop botherin me before i blow up your spot son.
Sam:i dare u.
Me:yo tameka you know sam just stopped eatin his boggers this year.
Tameka:Yo sam she just blew up your spot.
Sam:yo u just blew up my spot son.
Sam:i dare u.
Me:yo tameka you know sam just stopped eatin his boggers this year.
Tameka:Yo sam she just blew up your spot.
Sam:yo u just blew up my spot son.
by brooklyn-princess April 4, 2007
