Contrary to the number onedefinition, the muff is the culmination of the pussy and surrounding hair do... the muff can be characterized by its hair style, skin color, and smell.
In American football - when a punt returner calls for a fair catch or intends to let the ball bounce and be downed by the kicking team, and either drops the ball or otherwise touches it without taking possession resulting in a fumble that can be recovered by the kicking team.
And the punt is up.... oh it's a beauty - he got all of that one..... Devin Hester's back to receive it. He's waiving for fair catch and......... OH NO!! He's dropped it. Hester has muffed the kick!! And the Patriots recover. Hester, normally sure handed, has muffed another one. Not what the Ravens had in mind when they brought him in.
Muff (M.U.F.F.) - Mandatory Ugly Fat Friend. Something that follows every hot girl in order to make it difficult for you to enjoy your time with your hot friend. They are never enjoyable to be around; a muff's only purpose is to make it difficult to game on the hot girl you like.