Debbie Down Syndrome 

When somebody is acting liking a debbie downer, but is being retarded about it

Bill: Wow, the score is 12-11. It looks like its going to lose this game.
Matt: Wow, we're only down one point. You're being a real Debbie down syndrome

Debbie Down Syndrome by King Cunta August 12, 2017

ultra down syndrome deluxe 

When someone has 92 chromosomes.

Jeff:Takes ur shield potion in fortnite
You:Whats it like living with ultra down syndrome deluxe?
Jeff:It's alright, I get a lot of free stuff

ultra down syndrome deluxe by Bucket0011 May 16, 2018

Metastatic Down Syndrome

When someone is so stupid that a simple retard won’t do

Durning an operation. The attending surgeons asks the resident to pull on something so he can see. “Hey pull on that like you mean it”. The resident then pulls too hard and causes audible bleeding! Surgeon says “what is wrong with you? Do you have metastatic Down syndrome?”

Metastatic Down Syndrome by Silver dollar tranny October 28, 2020

Double Down Syndrome 

A temporary loss of judgment and higher reasoning capability that one may experience immediately after consumption of KFC's double-down sandwich. Initial symptoms may include confusion, euphoria, and slurred speech. These are soon followed by loss of physical coordination and language ability (several patients have been observed to repeatedly utter variations of the phrase "hurr herp derp"). Patients may then enter a trance-like state for prolonged, variable amounts of time. A full recovery is typical within a few hours to a few days, although in some cases lasting brain damage has been reported.

In the hospital, it was discovered that what psychiatrists initially believed to be severe mental retardation was nothing more than a case of Double Down Syndrome after a late lunch.

Double Down Syndrome by theloniius April 12, 2010

Berry Down Syndrome 

The irrational belief by employers and supervisors that making use of a BlackBerry phone during the business day will result in a lack of productivity. Micro managers are usually afflicted by this disorder.

Susie: I'm off. I'm going to call my friend for a ride home.
Jojo: Down. Susie, down. Down. Put it down.
Susie: What the hell are you talking about?
Jojo: Down, berry down. Put it down. Down, put the berry down. Down, put it down. Down. Down.
Susie: You have Berry Down Syndrome, get help!

Berry Down Syndrome by Jocko Tam July 18, 2009

dick down syndrome 

The physical state following a good dicking in which you find yourself dazed, both mentally and physically.

Girl I was fucked so hard last night I woke up with dick down syndrome

dick down syndrome by Ted_Bear November 16, 2016

Suck a Nigga Dick With Down Syndrome Day

On the 2nd of October, it will be the international day of giving African Americans with Down Syndrome, specifically males, oral sex.

Bro, I had no idea it was suck a nigga dick with down syndrome day!

Suck a Nigga Dick With Down Syndrome Day by inteligentfellow September 19, 2021