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Reddit/Internet slang stands for: Hold My (Cosmo)politan. This is the female equivalent to HMB-Hold My Beer.

These are the last words before someone does something awesome or gets injured. Not actually said by person but as a comment to a video or gif.
HMC I've got a race to win in heels. HMC(only the acronym in title and it's a video of a drunk women's shenanigans )
HMC by C J breezeway July 28, 2019
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abbr. Huge Monster Cock
Man, Brad Pitt has a HMC.
hmc by everyoneknows May 4, 2006
Related Words
AIM , Facebook , Twitter etc. acronym for : hit my cell
on my way to the mall , hmc .
hmc by randymaurice July 9, 2010
[Person one to person two who are both watching a street fighting friend] HMC while I help a friend out
HMC by UnSpamMe August 6, 2019
Hold my cock
Kinley-“drew get in the back seat”

Drew-“HMC”
Hmc by DrizzlemyNizzlefoshizzle December 27, 2017
Originating from random mathletes bored during the otherwise dull math meets which they attended, the phrase "HMC" is an abbreviation for "Hot Math Chick." Mathletes have been known to use the acronym sarcastically or more rarely seriously.
Man, check out the size of the polynomials on that HMC!
HMC by Tang April 18, 2005
After thinking HMC is an abbreviation of "Homocide" I quickly found out it is an initialism of "Hold my Cosmopolitan", the female version of "Hold my Beer"
"What does HMC mean?"
"I don't know. Maby Homocide?"
HMC by Xuos January 5, 2020