That one party member that always keeps religion checking and being a nuisance overall for the rest of the group. If that religion check didn't work the first time it's not going to work now!
A portmanteau of "alcohol" and "cajónes", alcajónes is akin to liquid courage. Essentially, when a person drinks enough alcohol, they gain extra confidence and some bigger cajónes.
Man, did you really tell Joe Pesci to go fuck himself? You've got some real alcajones/alcajónes!