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A deliberately caused, carefully engineered mass dieoff, whether of humans or of other animals. A dieoff sounds nicer because it "just happens," whereas a "killoff" requires a murderer or murderers to bring it about.
The authoritarian dictator planned and plotted the killoff over many decades and was now reaping the fruits of victory, worldwide mass genocide or omnicide, more politely termed depopulation.
killoff by vtology November 2, 2022
Related Words

Kill Off Killy 

Kill off Killy is an old Jamaican saying, meaning if someone takes the piss with you they need to get hurt.
Kill Off Killy by HBEATz November 13, 2016
Guy: “So I went to chick-fil-a and got some nuggies and a large lemonade. It was so good. I kinda forgot to get you some, but you can have some ice that’s left over from my drink if you want.”

Woman giving birth to his child: “Kimloff! You had ONE JOB!!!”
Kimloff by Mastershidder April 11, 2021
a finisher in krump means to end a dance battle with a combination of moves leading up to a move that will just end it all
that kill off was just too much to handle or game over killed off
kill off by the anthem May 22, 2012

Kill off the kids 

To ejaculate somewhere sperm is not intended to survive
I'm going to Kill Off The Kids on the floor of my bedroom.
Kill off the kids by CubedIce December 16, 2018

Kilhoffer 

Someone who has to come up with roasts because it makes him feel better about being such a little bitch himself.
Man, that dude is such a Kilhoffer!
Kilhoffer by Crash69 March 11, 2020