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To get out of one's depressed, moody state.
Joe needed to defunkify after moping around for a month since his girlfriend broke up with him.

Defuckify 

We need to defuckify this code set.
Defuckify by Mr Tiger April 28, 2015

defuckify 

"Maybe you should try to maintain something remotely resembling a sleep schedule."

"I have one -- it's just fucked up."

"Then maybe you should defuckify."

defuglification 

The process of making someone appear less fugly, usually with the application of makeup and in extreme cases with corrective surgery.
1) After her defuglification surgery, the girl no longer needed to wear a bag over her head everyday.

2) Defuglification, possibly along with therapy, is the final step to curing Ugly Duckling Syndrome
To take a shower and get off all the stank and funk. Originated from Anthony.
Yo I'm gonna go defunkify in the shower right quick.
defunkify by Anthony May 10, 2004

Defugilty 

A problem. Difficulty. As in, "I had a defugilty in printing the job for the customer. Our printer kept eating the paper."
Example: "I had a defugilty in printing the job for the customer. Our printer kept eating the paper."
Defugilty by Floyd Ply January 17, 2005