TWEAKER 

A Noun. A GIRL OR BOYTHAT IS KNOWN FOR SLEEPING WITH OR GIVES ORAL SEX TO PRACTICALLY THE WHOLE NEIGHBORHOOD.

A Noun. A GIRL OR BOY THAT IS KNOWN FOR SLEEPING WITH OR GIVES ORAL SEX TO NUMBERS OF PERSONS THROUGHOUT THE CITY.

TWEAKER IS USUALLY USED TOWARDS FEMALES, BUT IT IS NOT UNCOMMON TO USE IT TOWARD A MALE. BOYS ARE USUALLY CALLED THE "BURNING BOYS", THE EQUIVALENT OF "TWEAKER".
*SEE "BURNING" 2nd and 3rd definitions...*

JESSICA SIMPSON SLEPT WITH KIM KARDASHIAN'S BOYFRIEND REGGIE BUSH.

KIM -"Jessica slept with my boyfriend, and I heard that she slept with Common, Kanye, and Usher, and gave Ray J, and Nick Cannon oral sex,... She is a TWEAKER!!!"

TWEAKER by ANCIENTCHINESESECRET93 May 19, 2010

tweaker 

someone that drinks too many monster or other energy drinks and eats too much sugar or both and become twacked the fuck out like they are on methamphetamine.

kid: look what i bought, 2 monsters and 2 packs of twinkies.
me: damn kid u such a tweaker getting hyped up on that sugar and caffeine.
kid: lol

tweaker by skaterjack October 5, 2006

tweaker 

1)A male who masturbates frequently

2)Someone who sucks at everything they have ever tried.

1)That kid has been in his room alone all day. What a tweaker!

2)He is such a tweaker he should give up school and start giving handjobs for crack!

tweaker by UOIT shredderz January 20, 2005

Tweaker 

a hyperactive, annoying little kid

you are a tweaker

Tweaker by Jared Blash November 2, 2008

tweaker 

a tweaker is simply a weirdo, from that weird girl who stalks you, the weird witch lady who lives at number 3 to that crazy old guy with the massive beard who rides his bike around all day muttering. its useful to have in the vocab as it can be shouted with no risk of insult to the tweaker in question. by streachin the sylables it can be made into an almost bird like cry. if u like
tweeeeee-kaaaaaahh

"oh my god, this guy is a fucking stalker, what a tweaker"

"shit dude, did you see that matey wearin girls clothes, what a tweeker"

"whos that tweaker on a microscooter"

tweaker by purv of the gore May 5, 2007

tweaker 

A man or a female who jump at loud noises or are always freaked out by little things

"Holy shit Tim just totally tweaked at the car that passed by us, what a tweaker!"

tweaker by Diggyer December 28, 2005

tweaker 

Some one who twitters too frequently

Wow your sister is such a tweaker, I mean she has like 87 posts a day.

tweaker by BeanyStiney April 8, 2009