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In Greek Mythology she was a woman caught banging Poseidon of the altar of Athena. Athena got really pissed and made Medusa really ugly, with snakes for hair.
Medusa is one person that you don't wish to anger.
Medusa by Pagan chick June 7, 2005
A piercing on the center of the upper lip, below the septum.
Medusas, are in fact, very painful. They are not very common, but can still be found adorned on the bodies of body modification culture.
She pierced her Medusa while at the Body Art Expo.
Medusa by myspace.com/4509496 August 27, 2007

Medusa's hair 

A bowel movement comprised of many long, thin pieces which together, resemble the serpentine hair of Medusa.
Yo Cassius, I just shit Medusa's hair, I must have eaten too many grapes.
Medusa's hair by Ragnord November 6, 2007

medusalum 

seen in Jay-z's song Ghetto techno; a type of shot glass as tall as a six year old
Johnny Patrone haha, we got em,
ey I need a medusalum
not a magnum
I need a medusalum,
i need a bottle as tall as a 6 year old
medusalum by sj12sep January 16, 2010

Fat Medusa 

An insult worse than the likes of "your mom". Often used by those with a higher intelligence or beauty than the victem of the verbal assult. Derived from fat (an over eating side effect)and medusa (that bitch in greek mythology).
"Why you bein' such a bitch Kimberly?"

"Shut yo face you Fat Medusa!"

"Oooooooooo..."
Fat Medusa by DVD Player April 9, 2008

Medusa’s full service lodging facility that is uniquely beautiful and stylish. (Is a self-contained commercial establishment.) 

“A frequently visited place.”
Have you been to Medusa’s full service lodging facility that is uniquely beautiful and stylish. (Is a self-contained commercial establishment.) yet? Hear that it's frequently visited.