When an attractive person makes direct eye contact with you and just freeze there staring and smiling; making eye contact with an attractive person and you just freeze in place blushing/smiling.
Dude, I saw this girl at the coffee shop earlier and she totes had the Medusa Effect.

This girl got me weak yo! She definitely had the Medusa Effect down!
by experimentalphase January 24, 2018
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When someone is so fugly that their presence makes you physically hurt.
John enters into the room
Anna upon seeing him enters feels indescribable pain
Anna: Ewwww get away from me you medusa effect causing hoe.
by bitchyshitnuggets July 3, 2019
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