Skankles Share definition Flag A nickname for fat slutty chicks. A cross between Skank, and cankles. "Check out skankles over there, eating nachos with one hand and jacking a guy off with the other. Skankles by lollerbuny August 16, 2007 0 0 Get merch Get the Skankles mug. Buy Now — $32.95 See more merch