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That dude's tweked
tweked by cxxIII October 6, 2009
The state in which one is constantly bugging out.
AKA; Dave Schiavoni
that guy dave is such a tweaker
Tweaker by Punquen February 26, 2019
shane any guy named shane is a definite tweaker and you should keep at least ten feet away
“that shane guys coming i hear he’s a tweaker go to the other side of the road
tweaker by shahsnabdm June 23, 2019

DJ-Tweaker 

A Hardstyle DJ currently in the 9th grade based out of Coppell, Tx. an amazing DJ especially since he's only 14. His name is Tweaker not because he is a methhead but because he is always messing with something and never shuts up.
"Did you hear that new DJ-Tweaker song? its bad ass."
DJ-Tweaker by Jay33 October 18, 2009
Originated in Philadelphia

A female that has sex with a lot of males, possibly just to become popular of doing it because she feels like it.
If you let a boy and his friends have sex with you are considered a tweaker.
Tweaker by briight April 6, 2010
someone who just isnt right, or someone who is really good at something, ie tweaking a certain thing (or trick in bmxing)
"damn, that x-up was tweaked" "Jake is a tweaker, he nibbles those 360 nose pivot things all day"
tweaker by cellardoor4130 May 23, 2005