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Down Syndrome Strikeout

when two homosexual boys with down syndrome sit on a couch by a warm cozy fire and take turns giving each other oral sex then all of a sudden one of them unexpectedly shoves the other boys entire ball sack in his mouth and gnaws the stretched skin off and swallows it whole then rips off his own testicles and wedges them inside of his asshole then takes his hand and slaps himself across the face then yells at the other boy in laughter and excitement"STRIKE THREE I'M OUT" then jumps into the fireplace. The other boy crys in agony because he knows he was defeated by a true champion.
Sebastian- I wonder what people with Down Syndrome do with there free time.

Derrik- They play Down Syndrome Strikeout

Sebastian- Whats that like retard baseball?

Derrik- Lets just say the two are quite similar.

the strikeout 

Taking a hit from a bong, drink a shot and then chug a beer all before blowing out the smoke.
Did you see when that guy did the strikeout at the party last night?
the strikeout by MWR September 23, 2008

Verbal Strikeout

When somebody tries to either:

a. Tell a story
b. Say a sentence
c. Get a point across

but has to restart at least 3 times, you can call for a quick end to their speech by shouting "VERBAL STRIKEOUT". Three strikes you're out. The conversation must then make a complete shift and move on to another topic.
Guy 1: Hey man, last night was crazy, I was at a frat house and- well I was at my FRIENDS frat house then- but wait hold up- It might have been two days ago-

Guy 2: *rudely interrupts* YOU'RE OUT! Shut up now.

Guy 1: Wtf bro?

Guy 2: Verbal strikeout, duh.
Verbal Strikeout by 1337 Fork April 20, 2009

Looking Strikeout 

Part of the relationship base system. Means to not even ask someone out, thus making no progress.
Bro, how are thinks with you and Jill?

I decided to not ask her. I got a looking strikeout.
Looking Strikeout by jrush0815 September 18, 2016

Mexican Strikeout 

When you chase a double-shot of tequila with a double-shot of Tapatio. Optionally, the subject may also snort a line of salt as either the first or third step.
Jose drank so many Mexican Strikeouts that he did not even realize that he was the victim of double anal.
Mexican Strikeout by KelleyRoss August 14, 2009

Catholic League Strikeout 

When you do a whip-it and a line of heroin in the same breath. It's a "catholic league" strikeout because in the catholic baseball league there are only 2 strikes and 3 balls. The 2 strikes being the whip-it and heroin.
Holy shit, Jimmy just took a Catholic League Strikeout and can't move!