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To talk someone down is to speak to them in a soothing voice in an attempt to calm them down, especially when they're vomit-drunk or having a bad trip. This usually takes place behind or next to the person having a bad trip, in front of a bathroom mirror in a stranger's house while your best friend is curled up in a ball in the bathtub and someone already has the toilet.
I wanted to roll over and die after the third hit, but thanks to Derek talking me down I was okay.

She should be alright after a good talk down.
talk down by anglosaxophone October 25, 2015
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To speak to someone or about something in a condescending manner or tone.
Uncle Shane, why do you talk down about gay people all the time?
Talk down by D. Y. Vetz October 4, 2019
"Talk down" Something the girls said in junior high when they bragged they were better then Chelsie. Chelsie seemed good but I didnt know her like that. Girls can be so mean.
Girl 1 "Oh yes Chelsie is so uggs,"

Girl 2 "oh yes, talk down girl. Talk down."
Talk down by lefty three September 17, 2020

Talk down on my name 

If someone talks bad about you you say...

Talk me down 

To talk someone down, in an act to make them not do something. Most likely something harmful or life threatening, like suicide. To talk someone down off the metaphorical cliff they stand on.
I was on the brink of just ending it all, but my friend came and talked me down.

I have talked someone down from suicide.

I really just need someone to talk me down.
Talk me down by dkladored February 13, 2017