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1) Acronym used for the phrase "shut the fuck up" for efficiency reasons.
Please stfu because I am trying to read.
stfu by johnisthegame February 27, 2003
1.) Save The Freaking Unicorns
2.) Say, Thanks For Understanding
3.) Short Term Follow Up
4.) Special Task Force Union
5.) Stop Talking Find Username
6.) Slippery Teflon From Utah
7.) Stinky Telnet Fell Under
8.) Special Transitory Food Units
9.) Stealing Turkeys From Uncle
10.) Superior Tactical Fragging Unit
11.) Silence That Followed Us
12.) South Texas Farming University
13.) Southern Tenant Farmers Union
14.) Scrawny Two Faced Underling
15.) Samurai Training Finished Unsuccessfully
16.) Show Them Fury Unleashed

Or the most common definition:
17.) Shut The Fuck Up
The common response to the previous 16 definitions.
STOP GIVING ME MANY DEFINITIONS FOR STFU!! STFU!!
STFU by DarkDragon59 December 16, 2011
abbreviation for shut the f*ck up.

AKA::

Stop
Tickling
Furry
Unicorns.
shut the f*ck up dude.
no you stop tickling furry unicorns!
man, just stfu, stfu.
stfu by jujujuju100982563009lol August 18, 2013
You:lolololol I 5 year old ghjhfyh lmao get rekt lolol
Me:stfu kid
Stfu by Kill yourselves June 13, 2018
A song by Pink Guy.
Recommended when somebody is annoying you.
Random person: says something annoying
Me: plays STFU
STFU by Herr Shrek January 23, 2020