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a shit feeling that you get when all has failed.
I have so much dispair from not being accpted by the girl of my dreams i could just die!
dispair by maxinator February 12, 2006
(ebonics) referring to a card game
Shit! All I got is dispair of 3's
dispair by Sepio April 5, 2005

pit of dispair 

A dark, gaping, bottemless pit in which a man will sometimes fall into and never see his manhood again.
I loath the day i lost my way in that pit of dispair named Lucy, my purple helmet warrior has lost his fighting spirit.
The opposite of hope. It is something that hope will always defeat.
It is also something Nagito Komaeda dislikes.
We'll never give in to your despair.
Despair by hopebagelko June 30, 2017
A word meaning the complete absense of hope, popularized among pop culture by the video game series Danganronpa.
Person: “I’ve sunken into despair; I dropped my donut.”

Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her. 

Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her.
Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her.