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To use a lump of timber of about 2 by 4 inches in diameter to inflict blunt force trauma mainly to head or sometimes body. Generally easily available at short notice & fits comfortably into the average hand.
i'm guna 2 by 4 that bitch
fucker needs a good 2 by 4in
2 by 4 by seeingbunnies June 15, 2010
Hand me that red 2 by 4 piece over there.
2 by 4 by Flick Montana August 31, 2006

fatty fatty 2 by 4 

...can't fit through the kitchen door.

(does anyone know the rest of "skinny, skinny, 1 by 8?"
fatty fatty 2 by 4 by ty August 26, 2003

Fatty Fatty 2 by 4 

A jump rope rhyme that is quite obscene
Fatty Fatty 2 by 4
Couldn't get through the bathroom door,
So he did it on the floor,
Licked it up and did some more!
The art of performing sexual intercourse on a 4 legged animal, via the butt hole.
Call a "2 by 4" because a human has 2 legs, where as animals have 4
"Dude, Mark totally performed a successful 2 by 4 on Jamie's dog last night"
2 by 4 by MMjr April 21, 2008

fatty fatty 2 by 4 

I was walking down the sidewalk, and I had to get move into the street just so I could pass fatty fatty 2 by 4.