I see my colleague in the elevator on the way to the meeting room. I ask him how he is doing. He says, "I have been up all night to prepare this presentation for the board. I've been working on it non-stop for three days. I've been drinking coffees like a bandit to stay awake. I'm so toasted. I'm so wired, too. Man. Hell, I''m twired.
2. A nerd and "some other word combined." (This is definition might have come from the 1st one, but the people who haven't read Twilight or New Moon or Eclipse do not understand.)
Being so tired that your body tries to make up for it in a ridiculous level of stupidity. The result is an a very hyper (wired) person that you need to convince to sleep.
Twas the night before the exam, and the student was twired as all hell.