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Too exhausted to do anything, too wired to sleep.
I felt twired after drinking an espresso at 4:00 am.
twired by Carlyle Pollard January 7, 2004
Related Words
Twierd twerd twired tweird tierd Tiwerd twiend tweerd tweerdo Tweirdo
To be in a combined mental state of tired and wired.
I see my colleague in the elevator on the way to the meeting room. I ask him how he is doing. He says, "I have been up all night to prepare this presentation for the board. I've been working on it non-stop for three days. I've been drinking coffees like a bandit to stay awake. I'm so toasted. I'm so wired, too. Man. Hell, I''m twired.
Twired by Royal Wulff November 27, 2012
Someone under the influence/ high on meth who looks or is acting weird or strange in behavior(s).
Look here tweerdo, you're creeping me out. Sit your ass down over there and don't move.

Look over there, she looks like a tweerdo. Typical in the Independence walmart aisles.
tweerdo by SavagebeautyTK November 25, 2018
1. A twilight nerd

2. A nerd and "some other word combined." (This is definition might have come from the 1st one, but the people who haven't read Twilight or New Moon or Eclipse do not understand.)
Person 1: Oh my Cullen, I just got an Edward and Bella t-shirt!!

Person 2: Really?! Gimme gimme gimme!!!

Person 3: You both are such twerds

Person 1 and 2: Grrrr!!!
Twerd by Twerd May 26, 2008
A crude conjunction of the words "totally wierd"
Missy likes to lick the bleachers-that's tweerd!
tweerd by lizspittle April 10, 2007
Being so tired that your body tries to make up for it in a ridiculous level of stupidity. The result is an a very hyper (wired) person that you need to convince to sleep.
Twas the night before the exam, and the student was twired as all hell.
Twired by JJ Rylee October 24, 2016