When one's thumb and index finger grasps the victim's nipples resulting in a whale of pain. If a victim experiences nipple twisters often enough in his/her run of existence, he/she may have nipple cancer.

Nipple twisters are mainly given to males, often by males. But there is an occasional pervert who decides to bestow a nipple twister to the head cheerleader of the school, who happens to have her boyfriend behind her. Ouch...