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It's an essence extracted from someone's skull at the point of death.

It's highly euphoric and addictive. You don't feel anything while it's inside of you.

Amber Sweet (Paris Hilton) is addicted to it in Repo! The Genetic Opera. She has a sexual relationship with G-Rob who she gets it from.

It's generally used before getting surgery.

Though, it's highly abused.
(From Zydrate Anatomy)
GRAVEROBBER
Zydrate comes in a little glass vial.

SHILO
A little glass vial?

CROWD
A little glass vial!

GRAVEROBBER
And the little glass vial goes into the gun like battery.
And the Zydrate gun goes somewhere against your anatomy
And when the gun goes off, it sparks and you're ready for surgery.
Zydrate by NoahtheGreat October 31, 2008
Urban Dictionary Merch
Zydrate is a fictional drug. In the movie Repo! The Genetic Opera, Zydrate -a potent opioid extracted from dead bodies- is manufactured by GeneCo. as a prescription painkiller. Zydrate is injected with a Zydrate-Gun which uses an electric current to enhance the drug's analgesic effect.
Graverobber: Zydrate comes in a little glass vile.

Shilo: A little glass vile?

Junkies: A little glass vile!

Graverobber: And the little glass vile goes into the gun like a battery... And the Zydrate-Gun goes somewhere against your anatomy... And when the gun goes off it sparks and you're ready for surgery.
Zydrate by LJenna January 5, 2009
Related Words
A mixture of Mountain Dew Voltage and ecstasy (MDMA). Named after and inspired by the fictional drug of the same name from the movie Repo! The Genetic Opera.
Hey dude, I made some zydrate from some ecstasy we got at the club the other night.
Zydrate by Jehav July 2, 2009
Zydrate is a rare type of drug that helps relieve pain. It also gets you a bit high. Mainly scalpel sluts use this drug.
Amber Sweet is addicted to the knife, so in order for her to relieve her pain, she buys Zydrate from a Grave Robber.
Zydrate by xxRepoManxx January 16, 2009
More from Urban Dictionary
A group of people, typically women, searching through someone’s digital footprint in order to find more information about that person.
Susie wasn’t sure if her new Hinge match was a creep, so she assembled Galantir and they found out he used to post slurs on gaming forums.
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Word of the Day on September 23, 2026

murderhobo 

In a tabletop game, a murderhobo is a player who murders NPCs indiscriminately. This is normally derogatory, referring to a player who totally ignores quests, dialog, backstory, trade, world building etc.

The term is most common with Dungeons and Dragons, but it can be applied to most RPGs where the player is allowed to kill most quest-giving NPCs and NPC traders. E.g. Elder Scrolls, Fallout, Divinity original sin.
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Steve: I'd like to roll a strength check against strangling the orphan.
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murderhobo by Loup&S September 9, 2021
Word of the Day on September 22, 2026
In sales terms, a whale is a prospect that is significantly larger than an organization’s average customer.

Whales are large and extremely difficult to close. Due to their immense size, they are highly sought-after.

A whale is typically identified at first by a whale hunter on the sales team, but often requires cross-discipline participation in order to close; this includes assistance from operations, engineering, creative, client success, and business development teams.
"Shit...the sales director chewed me out on the sales call this morning. He's totally pissed that I have nothing in my pipeline. I've been focused on this one whale for so long that I haven't had time to prospect for normal-sized deals."
Whale by FQ_GFY February 3, 2020
Word of the Day on September 21, 2026
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