one of the only appropriate responses to something that makes absolutely no sense to you
Person 1: coffee u dont drink coffee? or are u just saying that cuz he recently had a bad drunk

Person 2: what's that now?
by smash9169 September 23, 2009
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Wait, what?

A quote from the TV series The Simpsons in the episode "Who Shot Mr. Burns pt. II," Jasper, a senior citizen says this quote.
Mitch: (in a meaningless argument with the person next to him while the rest of the world tunes them out) No, I'm positive it isn't done that way. Right Al?
Al: Who shot who in the what now?
by talkemotome52 March 24, 2008
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A rhetorical question used when one is in a difficult predicament and the circumstances suddenly change in his/her favor, such as when the person in trouble pulls out a gat or when his/her posse shows up ready to whoop some ass. Often followed by "bitch" or "punk" to further assert dominance.
Barack Obama: "Now that I've won the Iowa caucus, I have the Democratic nomination in the bag. The New Hampshire primary is going to be a walk in the park."
(Hillary Clinton wins New Hampshire primary)
Hillary Clinton: "Hell yeah! What's up now, bitch???"
(Barack Obama wins the Democratic nomination)
Hillary Clinton (obviously insincerely): "Congratulations, Senator Obama. I am so happy for you. The American people definitely made the right choice."
Barack Obama: "Three words, Senator Clinton: WHAT'S UP NOW?!?!?!"
by Nicholas D February 27, 2009
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Said after coming upon someone who has done or said something earlier deserving of a beating, which could not be administered due to circumstance.
You were talking smack earlier with your friends.....Whats up now!!
by Brett A August 18, 2006
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"Now what?" is a phrase signifying boredom, a lack of topics to discuss, or a greeting after a brief to intermediate pause in conversation. It is common to see the term "dunno" follow as a response.
Speaker 1: "Now what?"

Speaker 2: "Dunno."
by Blueberry Yum Yum March 27, 2008
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Repeated in a accusatory string, this bullying and demanding retort is screamed with spit and piss when one woman gains the upper hand in an argument.
TV Show Host: You ARE the father!

Show Guest/Baby Momma: NOW WHAT? NOW WHAT? NOW WHAT? NOW WHAT? NOW WHAT?
by jiminton August 10, 2012
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