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UOENO is a corruption of the phrase "You don't even know". Colloquial vernacular predominately used in the south eastern and central southern portions of the United States. It is an expression of someones' lack of knowledge about a certain situation, circumstance, person, or matter. Can also refer to the degree that someone lacks knowledge concerning a situation, circumstance, person, or matter.
My boss made me so mad to that I was ready to quit. UOENO!

also

I heard that Tami was hitting on you. (reply) UOENO
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The author, MS3MY, above is the most correct in that there is not a direct correlation between this acronym/abbreviation and its pronounciation.

"Yaint even know" is what these letters sound like when spat in sequence; however, all of the definitions above are also correct.
Controversy on "UOENO":

Rick Ross: Put molly up in her champagne, she aint even know it
Rick Ross: Then I took her home and I enjoyed that, she aint even know it
UOENO by Seatthell October 5, 2016
Related Words
"This a thousand dollar pair of shoes and UOENO it
This a thousand dollar cup of lean and UOENO it"
UOENO by Aine Treblig August 21, 2013

uenoyama 

Just the gayer Kageyama πŸ˜»πŸƒπŸƒπŸƒπŸƒ
β€œUenoyama-kun...Thank you. Th-β€œ
uenoyama by Gay_as_i_am October 26, 2020
The quick way to say "you ain't even know". pronounce every letter!
damn, bro, Haley is finee. she's definitely a 10

lol, uaeno!
uaeno by Furrrtd October 28, 2013
A term used to replace the phrase "you don't even know". Say uneno fast. And youll understand.
Uneno how much i spent on these shoes.
uneno by Mr. Shagotz December 2, 2013
the uyeno of that kid is strong...He's like the most popular kid in school.
Uyeno by Marcus February 25, 2004