1 definition by Urban Etymologist for Hire
UOENO is a corruption of the phrase "You don't even know". Colloquial vernacular predominately used in the south eastern and central southern portions of the United States. It is an expression of someones' lack of knowledge about a certain situation, circumstance, person, or matter. Can also refer to the degree that someone lacks knowledge concerning a situation, circumstance, person, or matter.
My boss made me so mad to that I was ready to quit. UOENO!
also
I heard that Tami was hitting on you. (reply) UOENO
also
I heard that Tami was hitting on you. (reply) UOENO
by Urban Etymologist for Hire April 20, 2013