When a fully clothed person goes up to another clothed person on the street and begins to hump them roughly
"Wow man that chic over there is really hot!" , "oh yeah I dare you to go over and street hump her as hard as you can"
by paraleel October 24, 2011
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That one block where all the prostitutes hang out for some reason.
"I saw Johnny heading toward 22 Hump Street"

"That horny bastard"
by September 6, 2021
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