Regional, mid-south US. From the Jerry Lee Lewis song "Drinkin' Wine Spo-Dee-O-Dee". Not quite an insult. The term is applied to one who is respected, yet inferior, or more often simply in a temporary state of inferiority, such as a friend who is being a stupid drunk.
as spoken to a friend who is hitting on fat girls and about to fall down some stairs: "whoa! careful there spo-dee!"

as a polite but firm and assertive warning to a transgressive stranger: "best keep off of my girl there spo-dee"
by XBJ-9000 December 14, 2003
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the act of a junkie, always sitting on the street corner begging dealers and others for a free hit.
man, jimmy always spo' taggin', when's he gonna get a job?
by Naveed Kovalchuk November 11, 2007
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Small problem overreaction Sydrome or SPO Sydrome

“Man, I hate the small rug in my bedroom

“Dude you have SPO Sydrome”
Man, you have SPO Sydrome”
by oO0Vibe0Oo August 1, 2020
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a hot 13 yr old kid who steals every girl he sees and he is the best person ever no cap and he is better than everyone
girl 1 :omg is ur crush spo???
girl2 : yasss!
girl 1 : samee!
by spo boi 69 February 3, 2022
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sexy piece of shit, a person who's sexy and a piece of shit
Hey you, you're not a piece of shit you're a spos!
by peachesuckgray June 19, 2019
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