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The act of removing a sister from your life, either physically or metaphorically. First used in the Simpsons episode "My Sister, My Sitter".
Simpson? Look, we've already been down there tonight for a sisterectomy, a case of severe butt rot, and a leprechaun fight. How dumb do you think we are?
by ubersmith May 17, 2016
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The act of removing the bitch from your life cause the only time you hear from her is when she wants something!
I really need to get a "Sisterectomy" so I can have a real life!
by LibertyCreekDrunkChick October 11, 2018
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