(verb) to have diarrhea
My baby has been running off since last night.
by SMXT March 27, 2009
When you get fired on a job site.
The safety man came around and i wasn't tied off. So I got run off.
by Welder77 April 20, 2009
To make a photocopy of something
Can you run off a couple of copies of that worksheet?
by chonk cat April 24, 2010
when ejaculation has occured past it's maximum point
Why is it still cumming like that?
I don't know. It's run off.
by Ben fuckermother August 27, 2003
fresh cum trickling down an object
Oh my, I've got run off on my back!
by Briannica November 6, 2004
An overwhelming excess of females, providing sexual attention towards an overtly attractive male. This one-to-many ratio results in several unattended females, creating an overflow or “run-off” effect. This pussy run-off is then collected by the inital target’s less attractive male friends and colleagues.
Justin Timberlake has way too much tail chasing him around. I wish I could be there to clean up his pussy run-off.
by SS-Chi-town August 11, 2018
When you cum in your OWN ass.

-Louie the 3RD.
"BRO she was riding me, didnt get the towel in time afterwards and I literally CAME in my own ass."
"Damn bro, you were a victim of the Mississippi run-off."
by Loutang3 August 13, 2019