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Run a block 

To have pseudo ownership of a neighborhood (or permission) to run illegal business through.

Whenever you hear a drug dealer talking about getting a block for their birthday, this is generally what they are talking about.

Usually given to them by higher ranking dealers or plugs. These people don’t literally own the block, but they have the power and respect to go uncontested from the people that inhabit it. Other unaffiliated dealers may try to steal your block through various means though.
Dealer A: You hear about Tommy?
Dealer B: Yeah, bro got Glenwood ave for his birthday

Dealer A: I can’t wait until I get a chance to run a block.
Run a block by ActuallyTalik February 10, 2023
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run a block 

when you're friend takes so long to reply online, the time it takes for them to reply back is the time you would take to run around a whole block
she's taking so long to reply again
i guess i could run a block
run a block by stitch-1807 June 18, 2010