pus-nuts Share definition Flag 1)derogatory term for a male cohort 2) gonorrhea 1) Hey, Pus-Nuts! Give me another beer, willya? 2) That's the worst case of pus-nuts ever to enter the clinic! pus-nuts by tolli March 17, 2004 0 0 Get merch Get the pus-nuts mug. Buy Now — $32.95 See more merch