Any bodily fluid that reqires clean up such as vomit, urine, blood, feces. This term is used most often in theme parks.
Nicole: "Hey Thomas, we've got another protein spill in the third car!"
Patty: "God, if I have to clean up another pound of upchucked popcorn I'm gonna quit!"
by Nicole Joy July 1, 2007
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Found it in the newspaper. Means: puke, vomit, throw up, upchuck, barf, spew, blow chunks, ralph, hurl, lose your lunch, be sick etc etc etc.
I'm always afraid my gf Holly's gonna protein spill when she blows me 'cause her gag reflexes are so fucking bad.
by Maurice April 27, 2004
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ohh noo yesterday..i was sipping tea with my grandmother and i told her that i suddenly had a involuntary protein spill!
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someone who puked, in VERY proper terms. just like there is no such thing as toilet paper anymore, now it's bathroom tissue.
the dinner my wife cooked was so disgusting that i became the participant of an involuntary personal protein spill!
by rockin' randall 1973 March 18, 2010
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