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a phrase used to express an attitude of somebody that is full of energy, vigor, perhaps rowdiness or excitedness.
Dottering Old Man: Well hello there young fella! How might you be feeling today?

Timmy: I'm full of piss and vinegar, you crotchety ol' coot! Now, outta my way, I'm going to play with my friends!

Dottering Old Man: Good to hear! Say, I'll give you a lollipop if you squeeze my testicles two or three times!
by Palcon_Funch July 14, 2011
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To be filled with bitter and angry thoughts because of someone/thing.
That Jade, she fills me with Piss and Vinegar. With her stupid... brother.
by ztara April 03, 2011
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