A puny, weak, frail person; someone who can easily be defeated. This kind of peron should not pick fights with a larger, stronger person.
Little guy: You're an asshole! Let's take this outside!

Big guy: Don't fuck with me or I'll break you in half, you fucking pipsqueak!
by Laura March 18, 2005
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A small person. A child or animal that is cute.
The pipsqueak is crying again.
by Morikahjo August 13, 2009
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The sound a rodent makes when squished with the weight of a penis but not crushed.
theathleticblackpapifromhorner: We were fucking in the park and I pulled out and my dick flopped on a squirrel. Best pipsqueak of all time.
by gr8m8696969696969 April 21, 2017
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