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one on one 

BASKETBALL, where you (and only you) play against one other person
I played against Santiago in a one on one basketball game
one on one by Home slice September 13, 2005

one on one 

An informal code of street fighting, not allowing bystanders to interfere in the fight.
Hey bitch-ass, let's square it up one-on-one in the midldle of the street!
one on one by PGrace August 4, 2003

one on one 

san francisco bay area slang for a combination of cocaine and heroin, aka a "speedball". a hit of tar heroin and powder cocaine sold together on the street for $10 to $20.
if youre in a san francisco neighborhood such as the mission, and you hear a guy calling out "one on oners, one on oners", hes not challenging you to a game of basketball.
one on one by beau "oma" taylor March 14, 2010

one on one 

1. When you go from dating someone to being in an exclusive relationship.
2. Becoming someone's boyfriend or girlfriend.
Friend 1: Dude, when are you guys gonna go one on one?
Friend 2: I'm not ready for a relationship yet.

Friend 1: I thought you were going one on one with her.
Friend 2: Naw, man. I don't want to give up the other pussy.
one on one by Juppy George January 16, 2009

one on one 

one on one by seliko June 17, 2003

one on one 

The phrase that people say that suck at everything but is the best in their little village where they live when they lose in a team-based. Normally followed by a really bad yo momma joke.
John: God dude, you really suck at everything.
Gaylord: what, you wanna go one on one, because I'm in your mom's bed.
John: (pause) Wow... really?
one on one by JoshRoxxx August 26, 2008