misterectomy 

When she finally divorces the bloke. A particularly difficult divorce from a very entangled relationship. A clean surgical break from a male spouse or partner from which the prognosis for recovery is improved functioning.

Judith finally underwent that desperately needed misterectomy. Too bad her HMO won't cover it.

misterectomy by paradigmtourist May 28, 2006

Misterectomy 

When a male has surgery that involves removing anything from the groin area.

The doctor told Dave today that a tube had developed between his colon and his bladder. Dave was shocked to hear that he needed a Misterectomy!

Misterectomy by The Baron Tube September 29, 2011

misterectomy 

Getting someone else to break up with your man for you

"Hey Todd, can you tell Brandon that I no longer want to see him?"

"So, you want to perform a misterectomy?"

"With as little pain as possible, thank you."

misterectomy by bensgirly August 22, 2011

sisterectomy 

The act of removing a sister from your life, either physically or metaphorically. First used in the Simpsons episode "My Sister, My Sitter".

Simpson? Look, we've already been down there tonight for a sisterectomy, a case of severe butt rot, and a leprechaun fight. How dumb do you think we are?

sisterectomy by ubersmith May 17, 2016

misdirectomy 

Accidentally sticking it in the butt instead of the vagina

Jon was on top of Kelsie when she said OUCH! Jon quickly appologized saying "sorry for the misdirectomy"

misdirectomy by JonRulZ October 26, 2010

mysterectomy 

Taking all the suspense out of a movie by revealing spoilers to someone who hasn't seen it.

"What are you watching?"
"The Village, I haven't seen it yet."
"Cool... you know it's set in the present, right?"
"Oh, goddammit! Thanks for the mysterectomy!"

mysterectomy by Ben Frey April 28, 2006

fisterectomy 

Removal of part or all of the uterus through an uppercut forceful enough to render the patient permanently barren.

Chelsea wouldn't shut up, so I had to perform an emergency fisterectomy.

fisterectomy by infinityfarmer October 4, 2013