Fo' shizzle ma' nizzle" is a bastardization of "fo' sheezy mah neezy" which is a bastardization of "for sure mah nigga" which is a bastardization of "I concur with you whole-heartedly my African American brother"
yo want to get high?

for shizzle my nizzle?
by niggawhat120 January 22, 2005
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Proof that society has got to the point that you can say retarded things like "shizzle my nizzle" without at least 13 people going "WTF?"
"Shizzle my nizzle"
"I get you..."
by Kay July 27, 2003
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