1. A polite and well meaning colloquialism. This phrase gained popularity when famed rapper/pornographer/movie star Snoop Dogg started using it and other words containing the suffix "izzle" or "izzy."

2. To informally aquiesce or agree with someone whom you consider an affable peer.
My friend Tim was like, "Whassup Dog, are you going to the game tonight?" I responded "Fo' Shizzle my nizzle" in the pitch of a tenor.
by Barry February 12, 2004
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For sure, my nigga. Should only be used by a black person, to a black person - unless you want your ass kizzled. Variations acceptable for use by whitey include:

fo' shizzle my sizzle = For sure, my sister.
fo' shizzle my bizzle = For sure, my brother.
Yes sir, Suge sir. Right away sir. = Please Suge, don't kill me.
Whitey 1: Hey man, are you going to the club tonight?
Whitey 2: Fo' shizzle, my bizzle. Right after I watch the game on my televizzle.
Whitey 1: Sorry Suge sir, don't kill him.
by udc March 12, 2003
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Archaic phrase used by African American slaves since the 17th century. A corruption of 'For shine his hall, my knees ill' it was used as a greeting by slaves who had to polish the floors of colonial mansions. Later became an unrelated greeting.
'Missie, missie - yo massah done made me polish dat whole corridor, an it done made my knees hurt terrible - fo' shizzle ma nizzle, an no mistake!' from 'Gone With The Wind' by Margaret Mitchell.
by Anonymous June 26, 2003
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A slightly aborted version of a declined McDonald's slogan:
Hamburglar: "Come robble my knobble."
by WASTELY March 16, 2003
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It comes from the greek expression "sysomi i isla" which means the whole island together.

It was a chant that the greek soldiers on the aegean islands were shouting when they were defending them against the Turks.
Elli and Stavros chanted that they were fo' shizzle my nizzle.
by spalks June 26, 2010
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An urban slang rendering of a common phrase in real estate, "For Sale By Owner."
Fo' Shizzle My Nizzle:
3 bedroom, 2 bath cape cod in desirable neighborhood. Close to schools, parks, and shopping. Asking $149,900.

request for deletion of definition from rancidmonkey:"This definition could not be correct. Real Estate agents, urban or otherwise, would never use slang to advertise. The meaning is also too formal to ever be used in everday conversation, such a word rendered in slang would be."
by rancidmonkey May 23, 2003
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nah, ya'lls know dat dis chea' mean, "for sure my endearing African-American acquaintance".
Thug 1: Dis' hea' be dat purple weezle that make you talk nasty shady shyt.

Thug 2: "fo' shizzle my nizzle, let me hit dat shyt.. (puffs purple weed)

Comment submittes with request to Delete: "It was very hard to follow this. It makes no difference to me if people talk like this but damn I hate it when people type like this. Wouldn't it seem like it would take more time to find the right keys for typed slang? If this was meant as a joke... never mind, but things like this bug me."
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