Commonly used as a word for "For Sure" or Yes I Agree fully.
Cracker1: Yoh! I'd tap that ass anyday.
Wannabe Cracker: Fo' Sho!
by Shak April 18, 2003
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A shot to the head.

It is said in the tv show Gangland when Do was describing a way to do a hit.
"We had a, uh two guys, we called them Double Trouble. One person would hit you in the body, which would drop you, and the other person would put the what we call the fo' sho'."
by daboodeef179 September 23, 2011
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