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Post-Endgame Depression Syndrome 

That despondent, can't get out of bed, don't want to watch another Marvel movie again, feeling you get after seeing Avengers: Endgame and knowing that the original Marvel Cinematic Universe Saga has come to an end.
I could barely wake up for work Friday morning after seeing the new Avengers movie. The Post-Endgame Depression Syndrome is really hitting me hard.

Avengers Endgame 

A MOVIE EVERYONE WILL SLAP YOU IF YOU SAY ANYTHING ABOUT THE MOVIE IN PUBLIC UNTIL SIX MONTHS AFTER IT COMES OUT
Did you hear about Marshall after he left Avengers Endgame and was talking about it with his friends? Everyone who passed by kicked, punched or tripped him. Hope that taught you a lesson about spoiling movies.

Post-Endgame Depression

The feeling of depression felt after watching Avengers: Endgame, as you enter the first stage of grief and refuse to accept that the original avengers saga is, in fact, finished.
"I haven't gotten out of bed since watching Avengers: Endgame" "Sounds like post-endgame depression"
Sure they just met but they're endgame. They'll get married one day.
Endgame by anthonynottony April 30, 2019
Pertaining to a couple you ship on a TV show that you hope ends the series together.
Chuck & Blair on Gossip Girl are endgame; they belong together.
Endgame by Shipper4life July 28, 2011
The ultimate agenda or desired consequence of a planned series of events (often elaborate and unknown to outsiders).

In the business world its ideally an ingenious business strategy for the purposes of market domination. In movies its often nefarious and the secret objective of a super villain.

However, an Endgame scenario does not need to be bad, it may ultimately be a miraculously good outcome for all, though usually a major component is the acquisition of power by the party who planned it, irrespective of the larger consequences to others, good or bad.

Informally, people may ask "what's your Endgame" after listening to your plans but not getting what the point of your plan actually is.

It's best used in relation to an ingenious plans that are in progress where the overarching goal (the Endgame) may not be obvious. Originates from the idea of playing lots of small games (or completing lots of tasks) in order to achieve a larger result.

Poor (or boring) use: the Endgame of a degree is to get a high paying job.

Okay use: the Endgame of a degree is to get yourself deeply involved in the universities alumni network, build relationships with specific people that otherwise would be difficult, and leverage all possible resources to launch a great business.

Great use (see example below).
Google's Endgame is to develop super machine intelligence and take over the world.
Endgame by JuicyCleric March 4, 2015