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the act of hooking up for the first time (see: prude). The term "depruded" is often used by teenagers and preteens in some parts of the country, who are currently attending junior high or high school. The term is most common in Philadelphia and New Jersey.
Girl 1: "Renee isn't a prude anymore."
Girl 2: "I know. Henry depruded her."
by lalalove<3 August 25, 2009
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Being kissed for the first time-- mainly kissing but hooking up is definitely depruded also
Are you serious she was depruded before you?
by Jhubjhbujybj September 03, 2016
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