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coo coo for cocoa puffs 

a strictly medical term, used to describe a patient or person that has delved into a realm of irrational, illogical and/or crazy thought processes; Affected with madness; insane to an exceeding degree characterized by weakness or feebleness; decrepit; broken; falling to decay; shaky; unsafe; foolish
See that guy trying to put that square peg into that round hole? I think he's gone coo coo for cocoa puffs!
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coocoo for coco puffs 

May refer to a state of condition of lacking common sense, or being merely ignorant to a situation. Not acknowledging a situation
Why do I have to explain this to him over and over again, I don't want to be with him any more. He's coocoo for coco puffs.