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1. When things go in your favor, albeit in a nerdy way.
A reference to a Simpsons episode in which Milhouse first complains about wearing his "dorky highwater shorts" but feels better when the floodwater "soaks his ankles" but leaves his cuffs "bone dry," at which point he exclaims "Alright, everythings coming up Milhouse."

Example: I was picked as the "Best Edward from Twilight Look-alike" at the Springfield Bi-Mon Sci-Fi Con. Looks like everything is coming up Milhouse.
by walkingblind September 10, 2009
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2
When all possible choices or venues have been exhausted with no favorable result.
I tried to find the DVD at Wal-Mart, Best Buy, Circuit City, even at the pawn shop, but everything's coming up Milhouse.
by herphosmanolin August 20, 2008
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