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To be in the process of either

-To be effortlessly winning at any form of gambling where one plays against The "house" or "bank". Now extended to also mean effortlessly winning at friendly card games or any form of gambling.

-To be pulverising the opposition when heavily outmubered. Can refer to massacres, brawls or anything similar.
"He was cleaning house at the craps table last night"

"He's cleaning house at the drugs den because he has a wicked AK."

"The undertaker is in the ring and is cleaning house."
by Gumba Gumba February 25, 2004
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When the head of a sex trafficking ring has the low-hanging fruit/snitches killed.
On Law & Order: Special Victims Unit, Season 16 Episode 1, half way through their main witnesses are being killed and Fin says "someone is cleaning house"
by yassgirl June 05, 2017
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