What Up is a phrase commonly used by Barney Stinson, usually heard at the end of a comically appropriate sexual comment, often accompanied by a high five. Its style varies from time to time as do most of Barney's catchphrases, being either high-pitched or low-pitched, oddly pronounced or even not verbally said.
Open bar for the guys, open casket for the ladies, what up!
by hakunama tata July 21, 2019
Get the what up mug.
Hello, my friend. What is up with urbandictionary.com? I think its great!
Gangsta: Yo, G-dog. What the hizzle is up wizzle tha urbandictionizzle? It's mellow scrill yo!
White guy: WTF?
Urbandictionary.com: DEFINITION: Hello, my friend. What is up with urbandictionary.com? I think its great!
White guy: Oh.
by alyssa69gaming2011 June 11, 2023
Get the Yo, G-dog. What the hizzle is up wizzle tha urbandictionizzle? It's mellow scrill yo! mug.
A form of speaking to someone, out side of saying hello.
POV: someone calls your phone…
You Answer: What up Doe so and so.
by LyricalLC July 27, 2023
Get the What up Doe mug.
Running from 2015 - 2017, "Whats up with" was a YouTube series by Peter Knetter. First episode "What's Up With: Sonic and the Black Knight" first aired on Nov 23 2015. The series was where Peter (Peter Knetter) talks to cardboard characters.

Peter (2015-17)
Silver (2015-17)
Shadow (2015)
Sonis (2015-2016)
Chuckles (2015-2016)

Mario (2016)
Nick (2017) *as of "Whats Up With: Sonic's Schoolhouse"*
"Whats Up With series" a YouTube series that is no longer being filmed
by aripods September 13, 2021
Get the Whats Up With series mug.
This phrase is used when you are engaging in physical contact after someone disrespects you
Person 1: I heard you were talking crazy?

Person 2: I was never?

Person 1: What up den boi talk crazy now.
by Asetoya king 101 November 6, 2023
Get the What up den mug.