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Tuesday weirds 

Phrase- When a hard weekend or 3 day weekend of various hard drugs like ecstasy or meth has the afterglow wear off and you're left with a weird panicky sober low feeling.

One may act weird or just want to isolate themselves. It is usually the beginning of introspection from the weekend's activities. Ordinary things may seem slightly different.

Origin: unknown. Popular with 90s and 00 college age kids.
I have the Tuesday weirds from rolling and doing Xanax all weekend. I gotta find a way to leave work, before I freak out.
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