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that's whats up good lookin out 

1. an expression of approval and thanks for a good deed, OR, 2. can be used in sarcasm to show disinterest in someone's actions or feelings
1. Miss Utility: "I'm not wearing any panties."
Tito: "That's whats up good lookin out!"
or
Danny: "I got laid off today. I need to look for a new job."
Tito: "That's whats up good lookin out?

That's what's up 

Meaning that you fully understand and/or agree and find yourself excited about the idea or suggestion proposed.
Friend 1: "Yeah so I'm thinking we chill before, and then hit the club by 9. Got mad beer at the crib anyway"
Friend 2: "That's what's up"
That's what's up by KelsBels April 5, 2008

That's What's Up 

To show approval of a person's achievement.
"You got accepted to Harvard? That's what's up, dude."

That's What's Up 

A way of agreeing to what the other is saying. Or if they ask you a question it can also mean that you are down to do what they're asking.
1:"Ay mayne, i got this killa, we blazinituptoday?"
2:"Shiiiit, that's what's up!"

that's what's up 

Something that is exciting, great, and agreeable.


cool the shit the bomb These are just a few synonyms.
"You won a million dollars? That's what's up!"
that's what's up by dd3953 December 30, 2008

that's what's up 

Originated in Philadelphia circa 1998. When discussing events that are of intrest to both parties. The person that didn't know what was going down would say that's what's up.
usally rhetorical.
Frank:Yo! There's a big concert at the spectrum tonite?
Jonny: that's what's up!
that's what's up by HRM SMK April 2, 2008